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	Provedor de dados BJMBR (2) Autor Han,Xiao (2) Hou,Guowei (1) Li,Jin-bo (1) Piao,Chun-li (1) Qian,Yan (1) Song,Wei (1) Wang,Haixiao (1) Wu,Xu (1) Zhang,Rui (1) Mais... Palavra-chave Body weight (1) Chemoresistance (1) Cisplatin (1) Diabetes (1) Gastric cancer (1) Ginsenoside Rg1 (1) Insulin resistance (1) MiR-4290 (1) Obesity (1) PDK1 (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2020 (1) 2018 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Ginsenoside Rg1 inhibits dietary-induced obesity and improves obesity-related glucose metabolic disorders BJMBR Li,Jin-bo; Zhang,Rui; Han,Xiao; Piao,Chun-li. Obesity and its consequent type 2 diabetes are significant threats to global health. Emerging evidence indicates that ginsenosides from ginseng (Panax ginseng) have anti-diabetic activity. We hypothesized that ginsenosides Rg1 could suppress dietary-induced obesity and improve obesity-related glucose metabolic disorders. Our results showed that ginsenoside Rg1 attenuated dietary-induced body weight gain and fat accumulation in white adipocyte tissue of mice fed a high-fat diet. Furthermore, we found that ginsenosides Rg1 not only decreased fasting glucose concentration and the 2-h postprandial glucose concentration, but also improved insulin resistance and glucose intolerance in those mice. Ginsenoside Rg1 also activated the AMPK pathway in vitro and in... Tipo: Info:eu-repo/semantics/article Palavras-chave: Diabetes; Ginsenoside Rg1; Insulin resistance; Body weight; Obesity. Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000400610 MicroRNA-4290 suppresses PDK1-mediated glycolysis to enhance the sensitivity of gastric cancer cell to cisplatin BJMBR Qian,Yan; Wu,Xu; Wang,Haixiao; Hou,Guowei; Han,Xiao; Song,Wei. The development of chemotherapy resistance significantly impairs the efficiency of chemotherapy, but the underlying mechanisms of chemotherapy resistance in gastric cancer (GC) are complicated and still need to be further explored. Here, we aimed to reveal the effects of miR-4290/PDK1 (pyruvate dehydrogenase kinase 1) axis on chemotherapy resistance of GC in vitro. The expression patterns of miR-4290 in GC tissues and cell lines were determined by real-time quantitative PCR. Kaplan-Meier was used to assess the relationship between miR-4290 expression levels and patients' overall survival. CCK-8 and flow cytometry technologies were applied to detect cell proliferation and apoptosis. The luciferase gene reporter assay was used to evaluate the interaction... Tipo: Info:eu-repo/semantics/article Palavras-chave: MiR-4290; PDK1; Cisplatin; Chemoresistance; Gastric cancer. Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2020000500604 Registros recuperados: 2 Primeira ... 1 ... Última

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